How often does the GLP-1 dose increase?

Typically every 4 weeks if you are tolerating it. Slower escalation is common with nausea — many people stay at a dose that works rather than reaching the maximum.

GLP-1 Titration Schedule Calculator — Semaglutide & Tirzepatide

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GLP-1 Titration

Dose schedule • By week

Medication

Current week on treatment

⚕️ Educational only — standard manufacturer schedules. Your prescriber may go slower if you have side effects. Not medical advice.

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Pick a medication to see the schedule

How GLP-1 Titration Works

Pick your medication.
Enter the week you're on.
See your current dose, the next step-up, and the full schedule to the maintenance dose.

Standard GLP-1 Dose Escalation

GLP-1 medications are titrated slowly — increased every 4 weeks — to reduce nausea and side effects while your body adjusts. Semaglutide (Wegovy) steps through 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg weekly, reaching the maintenance dose around week 17. Tirzepatide (Zepbound) steps through 2.5 → 5 → 7.5 → 10 → 12.5 → 15 mg, reaching maximum around week 21.

These are the standard manufacturer schedules; your prescriber may hold you at a lower dose longer if it controls appetite well or if you have side effects. Never increase faster than directed. This is educational, not medical advice.

GLP-1 Titration FAQ

How often does the dose increase? ▾

Typically every 4 weeks, as long as you're tolerating it. Slower escalation is common if you have nausea — many people stay at a dose that works rather than reaching the maximum.

Do I have to reach the maximum dose? ▾

No. The maintenance dose is whatever controls appetite with manageable side effects. Many people do well below the maximum. Your prescriber decides.

What if I miss a dose or restart? ▾

After a longer gap you may need to re-titrate from a lower dose to avoid side effects. Follow your prescriber's guidance — this tool only shows the standard schedule.

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